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EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages

One of these studies demonstrated a 1.7-fold higher recovery of toxic metabolites in those with Gilberts syndrome compared to controls [33], although a larger study only found a higher rate of recovery of toxic metabolites in those patients stratified by having the lowest UGT activity [28]

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Wang WY, Pearson AT, Kutys ML, Choi CK, Wozniak MA, Baker BM, et al

And ROS induced by photodamge of the skin can activate inflammasomes