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Limited data indicate vitamin B12 deficiency may contribute to menstrual irregularities (but more study is needed)

However, due to its synthetic nature it is also the least bioavailable and active (Hunt, Harrington and Robinson, 2014) Methylcobalamin: The first of our non-synthetic forms of B12 is methylcobalamin, a naturally occurring co-enzyme

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Mild reactions may resolve by discontinuing supplements, while severe symptoms may require medical intervention, such as supportive care or medication

A less common type of the genetic form comes from changes in the HJV or HAMP genes