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So if someone is low in B12 and they consume alcohol, they not only don't have enough B12 to help 'clear away' the alcohol toxins but they also risk increasing homocysteine levels which I believe is that feeling of heat/hangover that can persist when there isn't enough B12 to reset the body

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People using metformin for type 2 diabetes also face an increased risk of declining B12 levels, calling for the need for regular monitoring [Moeckel, L