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Decreased gene expression of fatty acid binding protein 3 in the atrium of patients with new onset of atrial fibrillation in cardiac perioperative phase

Gut microbiota and TMAO affect CVDs in various ways and interact with each other, and this link provides an opportunity to identify TMAO as a new therapeutic target to treat CVDs

"REM sleep deprivation during 5 hours leads to an immediate REM sleep rebound and to suppression of non-REM sleep intensity" (PDF)

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When multiple circuitries break down, patients come close to a point-of-no-return in which health appears definitely lost and therapeutic interventions appear likely impossible (Lpez-Otn and Kroemer, 2021)