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Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets

Further studies have shown the absence of GSH in T cells does not interfere with TCR signaling but leads to a failure to reprogram cellular processes needed for robust clonal expansion and prevents the induction of aerobic glycolysis and the increase in cell size associated with T cell activation (Klein Geltink et al., 2017)

Clarkson, B, Gee T, Arlin Z, Mertelsmann R, Kempin S, Dinsmore R, O'Reilly R, Andreeff M , Berman E, Higgins C, Little C, Cirrincione C, Ellis S

[DOI] [PubMed] [Google Scholar] 150.Labb A., Brignole-Baudouin F., Baudouin C

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