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Although the pathogenesis of nevi remains unknown, it has been suggested that the lesions are benign neoplasms

Many are surgically removed for aesthetics and relief of psychosocial burden, but larger ones are also excised for prevention of cancer, although the benefit is impossible to assess for any individual patient

Immunohistochemistry may be of value in making this distinction

The reason for the long wait is unclear, but it may be telling that the company that initially developed PT-141 (King Pharmaceuticals) was acquired in 2010 by Pfizer, which famously manufactures Viagra and had a vested interest in keeping PT-141 off the shelves until after Viagras patent expired in 2020

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