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The endogenous release of RNS, such as nitric oxide (NO ), is produced from L-arginine in reactions of catalyze by three main isoforms of nitric oxide synthase (NOS): epithelial NOS, neuronal NOS and inducible NOS, which are activated in response to various endotoxin or cytokine signals ( and form highly reactive molecules such as ONOO (Salisbury and Bronas, 2015