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This coexistence hints at DSIP's integration into broader hormonal regulatory networks

There are uses to be explored, and, potentially, properties we have yet to discover

Pratt et al., 2021)

After mutation of the PAZ RNA-binding pocket (F294A, Y311A), trigger variants with longer internal loops induced binding and polyubiquitylation no better than did the seed-only variant, supporting the idea that together, trigger-specific RNA trajectory and binding of the vacated PAZ pocket substantially contribute to ZSWIM8 selectivity for TDMD substrates

IGF-1 signaling reduces neuro-inflammatory response and sensitivity of neurons to MPTP