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Abbreviations BBB: Blood brain barrier BSP: Bisulfite sequencing PCR CNS: Central nervous system COVID-19: Coronavirus disease 2019 CpG: Cytosine-phosphate-guanine DML: Differentially methylated locus HCY: Homocysteine MS: Multiple sclerosis PET-CT: Positron emission tomography - computed tomography ROCF: Rey-Osterrieth complex figure ROS: Reactive oxygen species RT-qPCR: Real time quantitative polymerase chain reaction SARS-CoV-2: Severe acute respiratory syndrome coronavirus 2 TF: Transcription factor TFBS: Transcription factor binding site VCD: Visuoconstructive deficiency WHO: World Health Organization References Centers for Disease Control and Prevention (CDC)

S2) or phylogenetic diversity as measured by Faiths formula applied to the whole phylogenetic tree (Supplementary Fig

doi: 10.1111/dth.12852 15 MarascaCFornaroLMartoraFPiconeVFabbrociniGMegnaM

Intravenous Administration The way B12 injections are given, either intramuscularly or intravenously, affects how well they work

Its all about listening to your body and adjusting your plan based on how you feel and how your levels respond to treatment