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In particular, the glyoxalase I-catalysed isomerization of hemithioacetals involves the sequential formation of -hemithioacetal, deprotonation to form the enediol intermediate and its enantioselective reprotonation 3 , leading to the formation of enantiopure -hydroxythioesters 4,5,6 (Fig

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Dihexa was administered intraperitoneally (i.p.) at 0.5 mg/kg in phosphate buffered saline (PBS) on alternate days, commencing 15 days post-surgery and continuing through day 48, with control animals receiving PBS alone

Furthermore, GLS has been identified as the first rate-limiting enzyme in glutamine metabolism, which has emerged as a potential therapeutic target for tumours