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Cell Mol Life Sci

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Although it was originally characterized as a metastasis suppressor gene, its most well-characterized role is in stimulating the secretion of GnRH from GnRH neurons, in turn leading to gonadotrophin production from pituitary gonadotrophs

In addition, while a number of the agonists in Table 1 (Families 2-5) have norleucine at Rj, or an amino acid residue, in the practice of various embodiments of this invention a number of an amino acid residues (D or L) may be used at residue Ri, including without limitation, tyrosine, phenylalanine, aspartic acid, arginine, isoleucme, serine, histidine, glycine, cysteine, methionine, tryptophan, norvaline, ornithine, S-benzyl cysteine amino acid residues