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The DEGs were first screened based on a p_val_adj less than 0.05 (adjusted p-value, based on Bonferroni correction using all genes in the dataset) and an avg_log 2 FC above 0.4 (avg_log 2 FC: log fold-change of the average expression between PD and control groups

In the digestive system, histamine plays a vital role in regulating stomach function , which involves the action of intestinal diamine oxidase

By combining individual parameters/protocols (using methods such as multiple logistic regression) and adopting a multi-modal diagnostic approach, diagnostic sensitivity and specificity has been shown to increase in some studies [37, 100]