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doi: 10.1111/j.1399-6576.2009.02023.x

Zhang XP, Zheng G, Zou L, Liu HL, Hou LH, Zhou P, et al

Stress, alcohol, pollution, and aging burn through it faster than you make it, which is where topping it up comes in

In the SOD1 G93A transgenic mouse (a common ALS model), researchers observed that the mice develop an altered microbiome even before symptom onset [83]

However, experimental evidence suggests that they include increased concentration of the drugs in the hepatobiliary compartment, formation of reactive metabolites that covalently modify proteins and produce oxidative stress, and mitochondrial injury