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Yu H, Kim PM, Sprecher E, Trifonov V, Gerstein M

Not only is it safe, but it is highly recommended

His/His SULT1A1 + null GSTM1/GSTT1: Low SULT1A1 sulfation reduces the parallel catechol estrogen inactivation route increasing the proportion of catechol estrogens that remain available for quinone-forming oxidation

The established urinary threshold level of 150 g/mL may be reached (rarely, but possibly) in some individuals within 6-20 hours of taking some long-acting therapeutic formulations