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There is a higher risk of gastric carcinogenesis in patients infected with CagA-positive compared to CagA-negative strains ( Gastric cells can protect themselves against oxidative stress by producing scavenger molecules

Seephetdee et al., 2022)

Assay: GSH/GSSG in mouse HNC cells and cancer tissue

From a pharmacokinetic perspective, the herbs bioactive withanolides are metabolized in the liver, and emerging evidence of its hepatotoxic potential adds a critical layer of complexity