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7 In addition, FIN56-induced ferroptosis is related to autophagy, and inhibition of autophagy at different stages could weaken FIN56-induced lipid peroxidation and GPX4 degradation

Supporting nerve function: Vitamin B12 is also critical for maintaining healthy nerve function

Haney SL, Holstein SA

Since experimental data indicate [106] that mainly the vitamin B12 forms catalyzed by MMACHC are modified by glutathione, our initial calculations will focus on their modification process within the common cobalamin-glutathione mono-anion model

It has been shown that, like MPTP, rotenone treatment in animal models (1.53 mg/Kg/day/up to 3 weeks) reproduces features of PD such as bradykinesia, postural instability and/or rigidity, reduces the tyrosine hydroxylase-positive neurons in the substance nigra, induces a loss of striatal dopamine, and the accumulation of -syn and poly-ubiquitin positive aggregates in remaining dopaminergic neurons (Betarbet et al., 2003