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Nitric oxide is produced by the endothelial enzyme nitric oxide synthase (NOS3) as a signal molecule to induce vasodilation and by immune system cells at larger amounts by inducible NOS2, that result in the formation of more potent oxidizing species that can kill invading pathogens [8]

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Even healthy lifestyle changes, like spending more time outdoors, can increase environmental exposure and oxidative stress within the skin

IFN- can be used as one of the cytokines secreted by NK cells and T cells in the tumor microenvironment

High levels of anabolism, particularly de novo lipogenesis (Currie et al