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The stock solution was equilibrated at 37 C and 5% CO 2 for 24 h, aliquoted, and stored at 20 C for further use

ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and dysregulate its function, including loss of Gems and altered levels of small nuclear RNAs

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2.5 ALT and AST enzyme activity measurement To evaluate the degree of hepatic injury, the serum enzyme activities of key hepatic enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assessed

A study of 6522 patients found that 24 (0.4%) had experienced adverse reactions, the most frequent being anorexia, nausea, vomiting, and rash [29]