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Clinical Translation Challenges and Current Status of Clinical Trials While robust preclinical studies (including in vitro and in vivo models) compellingly demonstrate the potential of numerous Traditional Chinese Medicine (TCM) monomers, extracts, and formulas in treating hypoxic pulmonary hypertension (HPH) with mechanisms involving anti-inflammatory, antioxidant, and anti-proliferative effects on pulmonary artery smooth muscle cells (PASMCs), promotion of PASMC apoptosis, protection of endothelial function, and regulation of ion channels and signaling pathways significant challenges remain in translating these promising preclinical findings into clinical practice

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