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found that AS-IV can activate the Nrf-2/HO-1 signaling pathway, suppressing the expression of downstream inflammatory factors like IL-1 and IL-18, mitigating the DOX-induced inflammatory response, and reducing the extent of myocardial fibrosis ( TGF-1 is widely acknowledged as a potent inducer of collagen production by cardiac fibroblasts (Euler-Taimor and Heger, 2006), playing a crucial role in myocardial hypertrophy and fibrosis by activating fibroblasts and promoting collagen synthesis (Wei et al., 2020)

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Curcumin is non-toxic at doses up to 8,000 mg a day [60]

Detox in a supervised program allows doctors to use medications such as benzodiazepines and other supportive treatments to reduce withdrawal symptoms, lower the risk of complications, and keep you as safe and comfortable as possible, as recommended by all major health organizations, including the NIH