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Multidrug resistance-associated protein-1 (MRP-1)-dependent glutathione disulfide (GSSG) efflux as a critical survival factor for oxidant-enriched tumorigenic endothelial cells

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In tumors, persistent ROS elevation increases GSH synthesis and shifts the redox balance, creating a biochemical environment that selectively activates disulfide/diselenide linkers and metal-based GSH-depleting nanoplatforms

Another study identified 16 microglia subclusters in mouse brain tissue 3 days post-permanent distal MCAO