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More than a year later, in September 2013, the regulator rejected the application, asking the company to perform another well-controlled randomized trial to better determine the safety and efficacy of the investigational product

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Updated efficacy and safety of entrectinib in NTRK fusion-positive non-small cell lung cancer

While more human research is needed, current user feedback and practitioner insights suggest the following best practices: Standard Dosage Most users take 50100 mg per day , typically in divided doses (e.g., 2550 mg twice daily) to maintain stable blood levels

How will you measure and teach dose administration