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Importantly, recent clinical trials using such personalized interventions demonstrated improved glycemic control and reduced HbA1c in both prediabetic and newly diagnosed T2D when compared to a Mediterranean diet intervention [120, 121]

Additionally, they downregulated Matrix Metalloproteinases (MMP2 and MMP9), key mediators of uterine matrix degradation, and suppressed p-STAT3 signaling while enhancing p-IRS1 and p-PI3K expression, indicating improved insulin signaling in the uterine tissues

Survival was scored every other day throughout the lifespan and a worm was considered as dead when they did not respond to three taps

The spray should be applied up to three hours before bedtime to maximize sleep benefits

Data were acquired using the PRM mode