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Wu and Fuh, 2025

2013;8(6):e65957

Focus on nutrition first An important first question to ask is, how hard are you working out

Dontsov, A

Key Points More than 100 genetic loci have been associated with ankylosing spondylitis (AS), but together they explain less than 30% of AS heritability Multiple genes involved in antigen processing and presentation are associated with AS Investigation into the cellular sources and regulation of IL-17 production is crucial to understanding the pathogenesis of AS Cells involved in type 3 immunity produce IL-17 and include innate lymphoid cells and T cells Given the efficacy of the anti-IL-17 monoclonal antibody secukinumab in the treatment of AS, other therapies targeting type 3 immunity could also be effective Abstract Over the past 5 years, advances in high-throughput techniques and studies involving large cohorts of patients have led to considerable advances in the identification of novel genetic associations and immune pathways involved in ankylosing spondylitis (AS)