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In some countries and regions, it may be used as a prescription drug or research drug in specific medical or research institutions

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10.1186/s13046-025-03394-8 27

Single oral doses equivalent to 4 or more mg/kg amlodipine in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension

110 In fact, coronary artery disease in people without standard modifiable risk factors has been estimated to be responsible for 1.4 million deaths globally each year