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Their findings revealed a significant reduction in glucose production and expression of both G6pc and Pck1 in hepatocytes with NNMT overexpression and concurrent Sirt1 inhibition, compared to hepatocytes with NNMT overexpression alone

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N Engl J Med 343 : 923930 Mauras N et al

This dual approach supports energy, repair, inflammation, and metabolism more consistently, potentially delaying age-related decline