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In a mouse model of hepatocellular carcinoma, regulatory T cells (Tregs) with high IGF-1R expression presented increased PI3K/AKT/mTOR signaling and were able to produce more ATP, lactate and ROS, which contribute to enhanced immunosuppressive effects (72)

10.1038/ismej.2015.151 203

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Differential gene expression and subcellular targeting of Arabidopsis glutathione S-transferase F8 is achieved through alternative transcription start sites

The studies, led by Research Associate Yevgeniya Mironova, PhD, discovered that OPCs acutely alter the extracellular matrix as they begin to transform into oligodendrocytes, giving rise to a unique protein signature a Dandelion Clock-like Structure or DACS that surrounds each differentiating OPC