glutathione peroxidase cancer PDF] peroxidases as oncotargets Regulators of system xc−–glutathione-glutathione peroxidase

ROS or UV exposure disrupts Keap1s conformation, releasing Nrf2 to translocate into the nucleus, where it activates antioxidant enzyme genes to establish cellular defense systems (Kovac et al., 2015

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SASP in disease-associated glial and immune cells Although senescent cells have ceased dividing, they are far from being completely silent. On the contrary, they remain metabolically and transcriptionally active, actively secreting proinflammatory molecules

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Metabolite concentrations were normalized to the concentration of water calculated from unsuppressed water spectra, since variations in water content within the sample are expected to be much smaller than the variations in the metabolite level [52]