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Finally, we previously used an animal experiment to show that RGC loss in Nrf2 knockout mice was much faster after optic nerve damage was induced by crushing the nerve 41

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Therapeutic targeting of AT ER stress shows promise through chemical chaperone interventions

Overall, ferroptosis plays a crucial role in HD pathogenesis, and targeting ferroptosis represents a promising therapeutic strategy for HD (Figure 4F)

In recent years, increasing evidence has suggested that traditional Chinese medicine and its active monomers can inhibit hepatocyte ferroptosis, exerting a protective effect against alcohol-induced liver injury