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Recent studies demonstrate that curcumin significantly downregulates miR-21 (oncomiR suppression) while upregulating miR-34a/b/c by two- to four-fold in colorectal cancer cells ( p = 0.002), miR-138 ( p = 0.024), and miR-16 ( p = 0.0001) in human subjects, demonstrating systemic miRNA modulation ( Resveratrol targets the miR-200 family and miR-125b-5p for epithelialmesenchymal transition (EMT) inhibition

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Iron malabsorption can also be due to gastrointestinal disorders of autoimmune etiology (celiac disease, atrophic gastritis, IBD), which are often associated with autoimmune thyroid diseases [59, 60]

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In biological systems, retroactivity can be defined as a flow of matter between two modules in which the downstream module affects the dynamic behavior of the upstream module [35]