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As an isolated active ingredient in supplements it is quite unstable and must therefore be bound to natural stabilisers such as calcium or glucosamine in order to show sufficient bioavailability

Such reactions, which occur most often within the first several minutes of administration, have been generally characterized by sudden onset of respiratory difficulty and/or cardiovascular collapse

Safety animal and some human data profiles generally look good, but clinical fertility trials are sparse

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Corroborating these data, McGrady and colleagues observed no changes in pressure in the presence or absence of TRPV1 (McGrady et al., 2020