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The intracellular sequestration and the paucity of free extracellular haem-iron ensures that there is scarce availability of this essential nutrient for pathogens ( Figure 1 Iron levels are suspected to be low in the upper respiratory tract, with an estimated daily exposure of approximately 10-25 g or around 1/1000th of that encountered by the gastrointestinal tract (Smith and McCulloh, 2015

10.1073/pnas.79.1.71 52 DusiS.DoniniM.RossiF

doi: 10.1002/JLB.3HI0620-416R 137

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