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Description

8,9 The increasing number, mechanisms of action, variable efficacy, and overall complexity of therapies means that any physician managing UC requires a nuanced understanding of therapeutic application

Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation

doi: 10.1111/j.1742-4658.2011.08005.x Ng, Chai Ann, Hunter, Mark J., Perry, Matthew D., Mobli, Mehdi, Ke, Ying, Kuchel, Philip W., King, Glenn F., Stock, Daniela and Vandenberg, Jamie I

These changes markedly reduce its affinity for the insulin-like growth factor-binding proteins (IGFBPs) while retaining agonist activity at the IGF-1 receptor, characteristics that make it a useful reference ligand in growth-factor biology