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Activated protein phosphatase-1 rapidly dephosphorylates and deactivates HSL, causing a fall in the rate of lipolysis (73, 92, 100, 119, 143)

The elevated IGF-1 environment drives protein synthesis and lean mass accretion while the GH-mediated lipolysis preferentially mobilizes visceral and subcutaneous fat, particularly in the abdominal region

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Consider a patient in her mid-40s, call her Elena, who'd been seeing a dermatologist on the Upper East Side for a couple of years