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Zheng Su, [email protected] These authors have contributed equally to this work This article was submitted to Biofilms, a section of the journal Frontiers in Cellular and Infection Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Altogether, these interrelated mechanisms create a pathological environment and further progressive neuronal damage, forming the biological basis of neurodegenerative diseases

In transfected cells 79 and mammals 66 , BPA has a higher affinity for GPER than either ER or ER, and BPA binding to GPER activates Akt and ERK pathways 79 , consistent with changes we observed

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