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It is noteworthy that scientists revisited certain beliefs after several decades (Oskolkova 2022)

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Zhou and Xue, 2022)

10.1046/j.1365-2036.2000.00692.x 35 JiangH.ZhouY.LiaoQ.OuyangH

A similar procedure was used for the MD simulations of Ab DPcob following simulated annealing, with and RMSD cut-off of 1.0 , resulting in 100 clusters (15 for one binding pocket, 85 for the other) to ensure an exhaustive conformational sampling during docking, and an exhaustiveness of 25