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& Mazur, T

10 These authors found that stimulation of spinal neurokinin 1, NMDA, and non-NMDA receptors enhances spinal release of PGE2, which facilitates the release of spinal amino acids and peptides

Under physiological states, hypoxia often coexists with nutrient deficiency in the degenerated intervertebral disc (IVD), forming a complex stress microenvironment