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doi: 10.3923/ijp.2016.36.51 5 HabibMABParvinMHuntingtonTCHasanMR

This deficiency might contribute to neuron death caused by oxidative stress

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But there are several obstacles to the development of this senolytic approach such as the long-term effect of CAR-T cells therapy with possible aspecific toxicity in different organs 56 , the cost and the difficulty during process development 57 or the selection of non-exhausted T cells to generate efficient therapy 58,59

Even in research planning, some groups should not be exposed to it because the safety data is too thin or the theoretical risk is too high