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The compound extends that protective, regenerative capacity throughout the body particularly to tendons, ligaments, the vascular system, and the gut lining

10.1089/ars.2013.5814 7 AmponsahP

Further studies showed that LPS activates molecules such as tumor necrosis factor- (TNF-), endothelin (ET)-1 by binding to TLR4 on the EC membrane, which ultimately causes a rapid and reversible decline in P-gp activity (Hartz et al., 2006) ( Figure 1 )

The Broad Institute CMap provides powerful data but uses specific cell lines and conditions that may not perfectly represent all tissue types