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Translation to humans has not been confirmed in large clinical trials

(3) EDS experts endorse PRP as a valuable option before considering surgery for unstable joints

10.1002/smo.20240052 60 Lopez-MitjavilaJ

Current strategies to treat or reverse fibrosis focused on targeting myofibroblasts include inducing apoptosis or senescence, promoting dedifferentiation to fibroblasts and reprogramming into other cell types 11

Research has identified potential interactions with NMDA receptor modulation and MAPK signalling pathways, with data suggesting structural homology to glucocorticoid-induced leucine zipper (GILZ) a protein involved in anti-inflammatory and immune-regulatory signalling via the ERK pathway