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Short NJ, Konopleva M, Kadia TM, Borthakur G , Ravandi F, DiNardo CD, Daver N

Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity

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As a triple agonist targeting GIP, GLP-1, and glucagon receptors simultaneously, it may surpass even tirzepatide for weight loss based on early clinical data

Using a whole-body IL-6 knockout mouse model of exercise and surgical LAD ligation, it was observed that IL-6 may be an important mediator of exercise preconditioning against both ventricular dysrhythmias and tissue death