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Abbreviations 6-OHDA6-Hydroxydopamine, AAmyloid-beta, ADAlzheimers disease, AKT/AktProtein kinase B, APPAmyloid precursor protein, BDNFBrain-derived neurotrophic factor, BBBBloodbrain barrier, CATCatalase, CurCurcumin, CuroilCurcumin oil, DOPAC3,4-Dihydroxyphenylacetic acid, GFAPGlial fibrillary acidic protein, GPxGlutathione peroxidase, GSH/GSSGReduced/oxidized glutathione, HSP70/HSP90Heat shock proteins, ICV/i.c.v.Intracerebroventricular, i.p.Intraperitoneal, IL-1Interleukin-1 beta, IL-6Interleukin-6, iNOSInducible nitric oxide synthase, JNKc-Jun N -terminal kinase, MDAMalondialdehyde, MCAOMiddle cerebral artery occlusion, MMP-9Matrix metalloproteinase-9, MPTP1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Nrf2Nuclear factor erythroid 2-related factor 2, NMSSNon-Motor Symptoms Scale, NGFNerve growth factor, NONitric oxide, OGD/ROxygen-glucose deprivation/reperfusion, PETPositron emission tomography, PDParkinsons disease, p--synPhosphorylated alpha-synuclein, PI3KPhosphoinositide 3-kinase, Prdx6Peroxiredoxin 6, ROSReactive oxygen species, SODSuperoxide dismutase, STZStreptozotocin, THTyrosine hydroxylase, TH + neuronsTyrosine hydroxylase-positive neurons, TNF-Tumor necrosis factor-alpha, Y-mazeBehavioral test for spatial working memory, ZO-1Zonula occludens-1