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The specific manifestations are as follows: In terms of overall structural and phylum-genus level alterations, multiple cohort studies have confirmed that the alpha diversity of intestinal microbiota in patients with early RA is significantly lower than that in healthy individuals ( Faecalibacterium , Blautia and Escherichia-Shigella were elevated, while those of Bacteroides and Coprococcus were reduced

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[DOI] [PMC free article] [PubMed] [Google Scholar] 319.Dons E., Laeremans M., Orjuela J.P., Avila-Palencia I., Carrasco-Turigas G., Cole-Hunter T., Anaya-Boig E., Standaert A., De Boever P., Nawrot T., et al