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Collectively, these data demonstrate that B 12 operates in a cell-intrinsic manner during in vitro reprogramming and that it is a limiting factor for SAM generation and successful reprogramming in vitro

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The addition of semaglutide to this already high-risk group showed further b12 decline, but whether this represents a medication effect, dietary changes from additional appetite suppression, or natural progression of post-surgical deficiency remains unclear

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