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Although PYC has been shown to reduce CRP levels, existing trials are limited by small sample sizes (e.g., five studies totaling approximately 324 participants in a CRP meta-analysis), high heterogeneity (I 2 99%), and variability in dosing regimens, treatment duration, and study populations ( Similarly, although PYCs anticancer effects have been demonstrated in multiple cell lines and preclinical models, translational data remain limited

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it is likely that disease manifestation occurs when multiple risk factors coalesce

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doi: 10.1038/s41598-019-44765-4 149 LiuYHuangZLiuHJiZAroraACaiDet al