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Based on their subcellular localization, TLRs are categorized into two major groups: cell surface-localized TLRs (e.g., TLR1, TLR2, TLR4) that act at the plasma membrane, and intracellular TLRs (e.g., TLR7, TLR8, TLR9) that function within endosomal or cytoplasmic compartments ( Figure 3 )

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Thus, parasite-induced reduction in MMP-9 expression in tumor-associated macrophages resulted in the suppression of tumor angiogenesis

Personalized, evidence-based exercise interventions hold great promise as adjunct therapies in BC care, but more rigorous research is necessary to unlock their full potential