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The absence of PINK1 inhibits PINK1-dependent mitophagy, and although cells may clear mitochondria through other pathways, the efficiency of their elimination is reduced, resulting in the accumulation of damaged mitochondria, iron, and synuclein alpha (SNCA) or even ferroptosis in the substantia nigra of PD patients [176, 177]

The BBB relies heavily on tight junction proteins to maintain its integrity and selective permeability [70]

Glutathione plays a vital role in preserving brain health by increasing glutathione levels

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Tamoxifen also leads to nonalcoholic steatohepatitis [8,43]