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[26] A complication of severe chronic PA is subacute combined degeneration of spinal cord, which leads to distal sensory loss (posterior column), absent ankle reflex, increased knee reflex response, and extensor plantar reflex response

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The studies below cover the key findings for each compound individually

Its nine-amino-acid sequence (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) and the unusual presence of a phosphorylated serine residue have made it a persistent subject of interest in neuropeptide and chronobiology research