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Most headaches associated with GLP-1 therapy are mild to moderate and resolve within 46 weeks as your body adjusts

However, it is wise and advisable to consult your health care professional before taking a food supplement

Ueda H, Narumi K, Sato Y, Furugen A, Kobayashi M, Iseki K (2020) Evaluation of possible pharmacokinetic interaction between methotrexate and proton pump inhibitors in rats