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These represented single and multiple amino acid substitutions and were characterized with a spectrum of metrics including binding, cellular activity, activity in a p53 independent counter-screen, circular dichroism spectroscopy, experimental LogD, calculated ALogP, solubility, NanoClick permeability 22 , and membrane disruption (as measured by lactate dehydrogenase (LDH) cytoplasmic release), (Supplementary Data 1)

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This protein contributes to the strength and elasticity of many tissues and organs throughout your body

Genetic CH animal models have relatively stable phenotypes without surgical trauma and are technically easy to handle and maintain 11

Surgical and facility costs for outpatient implantation procedures add approximately $10,000